An Overview of P450 Enzymes: Opportunity and Challenges in Industrial Applications: Article No. 152

Sandra Notonier, Alexander Meyers

Research output: Contribution to journalArticlepeer-review

Abstract

Cytochrome P450 enzymes (P450s) containing a heme-iron center, are biocatalysts from all kingdoms, involvedin a large variety of reactions. Their potential in catalyzing a broad range of substrates makes perfect candidates for biotechnology applications and the production of high-value compounds. Biocatalytic reactions performed by P450s have a great interest in the pharmaceutical industry, fine chemicals, cosmetics, and for bioremediation procedures. However, the complex nature of this protein is still a major hurdle in the prospect of using their promising ability for expanding the number of industrial applications. Multiple approaches of protein engineering are currently conducted to improve activity, stability and/or substrate specificity for a given reaction. Furthermore, in combination with the appropriate biocatalyst, a suitable bioengineering process is a key step in the implementation of P450s at the industrial scale.
Original languageAmerican English
Number of pages5
JournalEnzyme Engineering
Volume5
Issue number3
DOIs
StatePublished - 2016

NREL Publication Number

  • NREL/JA-5100-71788

Keywords

  • biotechnology applications
  • cytochrome P450 enzyme
  • limitations P450-based reactions

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