Biotechnology for Secure Biocontainment Designs in an Emerging Bioeconomy

Kathleen L. Arnolds, Lukas R. Dahlin, Lin Ding, Chao Wu, Jianping Yu, Wei Xiong, Cristal Zuniga, Yo Suzuki, Karsten Zengler, Jeffrey G. Linger, Michael T. Guarnieri

Research output: Contribution to journalArticlepeer-review

20 Scopus Citations


Genetically modified organisms (GMOs) have emerged as an integral component of a sustainable bioeconomy, with an array of applications in agriculture, bioenergy, and biomedicine. However, the rapid development of GMOs and associated synthetic biology approaches raises a number of biosecurity concerns related to environmental escape of GMOs, detection thereof, and impact upon native ecosystems. A myriad of genetic safeguards have been deployed in diverse microbial hosts, ranging from classical auxotrophies to global genome recoding. However, to realize the full potential of microbes as biocatalytic platforms in the bioeconomy, a deeper understanding of the fundamental principles governing microbial responsiveness to biocontainment constraints, and interactivity of GMOs with the environment, is required. Herein, we review recent analytical biotechnological advances and strategies to assess biocontainment and microbial bioproductivity, as well as opportunities for predictive systems biodesigns towards securing a viable bioeconomy.

Original languageAmerican English
Pages (from-to)25-31
Number of pages7
JournalCurrent Opinion in Biotechnology
StatePublished - Oct 2021

Bibliographical note

Publisher Copyright:
© 2021 The Author(s)

NREL Publication Number

  • NREL/JA-2700-79907


  • bio-design
  • biocontainment
  • bioeconomy
  • GMO
  • multi-omics


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