Catalytic Amino Acid Production from Biomass-Derived Intermediates

Eric Karp, Gregg Beckham, Weiping Deng, Yunzhu Wang, Sui Zhang, Krishna Gupta, Max Hulsey, Hiroyuki Asakura, Lingmei Liu, Yu Han, Paul Dyson, Jianwen Jiang, Tsunehiro Tanaka, Ye Wang, Ning Yan

Research output: Contribution to journalArticlepeer-review

169 Scopus Citations


Amino acids are the building blocks for protein biosynthesis and find use in myriad industrial applications including in food for humans, in animal feed, and as precursors for bio-based plastics, among others. However, the development of efficient chemical methods to convert abundant and renewable feedstocks into amino acids has been largely unsuccessful to date. To that end, here we report a heterogeneous catalyst that directly transforms lignocellulosic biomass-derived α-hydroxyl acids into α-amino acids, including alanine, leucine, valine, aspartic acid, and phenylalanine in high yields. The reaction follows a dehydrogenation-reductive amination pathway, with dehydrogenation as the rate-determining step. Ruthenium nanoparticles supported on carbon nanotubes (Ru/CNT) exhibit exceptional efficiency compared with catalysts based on other metals, due to the unique, reversible enhancement effect of NH3 on Ru in dehydrogenation. Based on the catalytic system, a two-step chemical process was designed to convert glucose into alanine in 43% yield, comparable with the well-established microbial cultivation process, and therefore, the present strategy enables a route for the production of amino acids from renewable feedstocks. Moreover, a conceptual process design employing membrane distillation to facilitate product purification is proposed and validated. Overall, this study offers a rapid and potentially more efficient chemical method to produce amino acids from woody biomass components.

Original languageAmerican English
Pages (from-to)5093-5098
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number20
StatePublished - 2018

Bibliographical note

Publisher Copyright:
© 2018 National Academy of Sciences. All Rights Reserved.

NREL Publication Number

  • NREL/JA-5100-71523


  • Acids
  • Amination
  • Amino acids
  • Catalysis
  • Ruthenium
  • Α-hydroxy


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