Catalytic Bias in Oxidation-Reduction Catalysis

David Mulder, John Peters, Simone Raugei

Research output: Contribution to journalArticlepeer-review

11 Scopus Citations


Cataytic bias refers to the propensity of a reaction catalyst to effect a different rate acceleration in one direction versus the other in a chemical reaction under non-equilibrium conditions. In biocatalysis, the inherent bias of an enzyme is often advantagous to augment the innate thermodynamics of a reaction to promote efficiency and fidelity in the coordination of catabolic and anabolic pathways. In industrial chemical catalysis a directional cataltyic bias is a sought after property in facilitating the engineering of systems that couple catalysis with harvest and storage of for example fine chemicals or energy compounds. Interestingly, there is little information about catalytic bias in biocatalysis likely in large part due to difficulties in developing tractible assays sensitive enough to study detailed kinetics. For oxidation-reduction reactions, colorimetric redox indicators exist in a range of reduction potentials to provide a mechanism to study both directions of reactions in a fairly facile manner. The current short review attempts to define catalytic bias conceptually and to develop model systems for defining the parameters that control catalytic bias in enzyme catalyzed oxidation-reduction catalysis.

Original languageAmerican English
Pages (from-to)713-720
Number of pages8
JournalChemical Communications
Issue number6
StatePublished - 18 Jan 2021

Bibliographical note

Publisher Copyright:
© 2021 The Royal Society of Chemistry.

NREL Publication Number

  • NREL/JA-2700-78211


  • biocatalysis
  • catalysis
  • catalytic bias
  • oxidation-reduction


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