Catalytic Carbon-Carbon Bond Cleavage in Lignin via Manganese-Zirconium-Mediated Autoxidation: Article No. 862

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Abstract

Efforts to produce aromatic monomers through catalytic lignin depolymerization have historically focused on aryl-ether bond cleavage. A large fraction of aromatic monomers in lignin, however, are linked by various carbon-carbon (C-C) bonds that are more challenging to cleave and limit the yields of aromatic monomers from lignin depolymerization. Here, we report a catalytic autoxidation method to cleave C-C bonds in lignin-derived dimers and oligomers from pine and poplar. The method uses manganese and zirconium salts as catalysts in acetic acid and produces aromatic carboxylic acids as primary products. The mixtures of the oxygenated monomers are efficiently converted to cis,cis-muconic acid in an engineered strain of Pseudomonas putida KT2440 that conducts aromatic O-demethylation reactions at the 4-position. This work demonstrates that autoxidation of lignin with Mn and Zr offers a catalytic strategy to increase the yield of valuable aromatic monomers from lignin.
Original languageAmerican English
Number of pages12
JournalNature Communications
Volume15
DOIs
StatePublished - 2024

NREL Publication Number

  • NREL/JA-2A00-85269

Keywords

  • acetyl vanillin
  • autoxidation
  • biomaterials
  • catalytic bioconversion
  • lignin depolymerization
  • lignin valorization
  • muconic acid
  • reductive catalytic fractionation

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