Chimeric Enzymes for Conversion of Lignin-Derived Chemicals

Christopher Johnson (Inventor), Gregg Beckham (Inventor), Jeffrey Linger (Inventor), Ellen Neidle (Inventor), Mark Eiteman (Inventor), Melissa Tumen-Velasquaz (Inventor), Alaa Mahmoud Ahmed (Inventor)

Research output: Patent


Disclosed herein are enzymes useful for the dealkylation of aromatic substrates, including the conversion of guaiacol or guaethol to catechol. Methods of converting aromatic substrates found in lignin-based feedstocks such as pyrolysis oil into products such as catechol are also disclosed. Also presented herein are methods for rapidly evolving and optimizing genetic regions.
Original languageAmerican English
Patent number10,087,425 B2
Filing date2/10/18
StatePublished - 2018

NREL Publication Number

  • NREL/PT-5100-72565


  • aromatic substrates
  • catechol
  • dealkylation
  • enzymes
  • feedstocks
  • guaethol
  • guaiacol
  • lignin
  • pyrolysis


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