@misc{6f073e48b6bd4975b3df8ca0d828be72,
title = "Computational Fluid Dynamics of Bioreactors with Micro-Aeration",
abstract = "Recent work has probed the potential for using Zymomonas mobilis as a flexible platform for the production of advanced fuels and intermediates. One set of recombinant organisms requires a micro-aerobic environment to promote the production of the desired product (2,3-BDO), but the economics and process-control implications of this approach are uncertain at industrial scale. Computational multi-physics models have the potential to describe the fermentation in detail at multiple scales, reducing the risk of scale-up. A two-phase Euler-Euler CFD model is used alongside a simple model of oxygen uptake to describe this bioreaction. A few reactor vessels, including airlift and CSTR bioreactors, are analyzed at multiple scales, regions of oxygen-depletion and over-oxygenation are characterized, and the bioreactors are compared. We show that it is difficult to achieve homogenous oxygen concentrations in industrial-scale CSTR reactors and that advanced bioreactor designs are needed for economical operation.",
keywords = "BCPL, biofuels, bioreaction, bioreactor designs, economic production, reactor vessels",
author = "James Lischeske and Mohammad Rahimi and Hariswaran Sitaraman and Jonathan Stickel",
year = "2019",
language = "American English",
series = "Presented at the Symposium on Biotechnology for Fuels and Chemicals, 27 April - 2 May 2019, Seattle, Washington",
type = "Other",
}