Considerations for Domestication of Novel Strains of Filamentous Fungi

Randi Pullen, Stephen Decker, Venkataramanan Subramanian, Meaghan Adler, Alexander Tobias, Matthew Perisin, Christian Sund, Matthew Servinsky, Mark Kozlowski

Research output: Contribution to journalArticlepeer-review

Abstract

Fungi, especially filamentous fungi, are a relatively understudied, biotechnologically useful resource with incredible potential for commercial applications. These multicellular eukaryotic organisms have long been exploited for their natural production of useful commodity chemicals and proteins such as enzymes used in starch processing, detergents, food and feed production, pulping and paper making and biofuels production. The ability of filamentous fungi to use a wide range of feedstocks is another key advantage. As chassis organisms, filamentous fungi can express cellular machinery, and metabolic and signal transduction pathways from both prokaryotic and eukaryotic origins. Their genomes abound with novel genetic elements and metabolic processes that can be harnessed for biotechnology applications. Synthetic biology tools are becoming inexpensive, modular, and expansive while systems biology is beginning to provide the level of understanding required to design increasingly complex synthetic systems. This review covers the challenges of working in filamentous fungi and offers a perspective on the approaches needed to exploit fungi as microbial cell factories.
Original languageAmerican English
Pages (from-to)343-362
Number of pages20
JournalACS Synthetic Biology
Volume14
Issue number2
DOIs
StatePublished - 2025

NREL Publication Number

  • NREL/JA-2700-93971

Keywords

  • filamentous fungi
  • microbial cell factory
  • molecular biology
  • synthetic biology

Fingerprint

Dive into the research topics of 'Considerations for Domestication of Novel Strains of Filamentous Fungi'. Together they form a unique fingerprint.

Cite this