Conversion of Biomass to Useful Intermediates

Gregg Beckham (Inventor), Christopher Johnson (Inventor), Derek Vardon (Inventor)

Research output: Patent


An aspect of the present disclosure is a microbial cell that includes a genetic modification resulting in the expression of a deficient form of an endogenous dioxygenase, and a gene encoding an exogenous dioxygenase and a promoter sequence, where the endogenous dioxygenase includes PcaH and PcaG, the exogenous dioxygenase includes LigA and LigB, the microbial cell is capable of growth utilizing at least one of a cellulose decomposition molecule or a lignin decomposition molecule, and the microbial cell is capable of producing 2-hydroxy-2H-pyran-4,6-dicarboxylic acid.
Original languageAmerican English
Patent numberUS 10,253,338 B2
Filing date9/04/19
StatePublished - 2019

NREL Publication Number

  • NREL/PT-2A00-73706


  • biomass
  • cellulose decomposition
  • exogenous dioxygenase
  • gene encoding
  • lignin
  • promoter sequence


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