Editorial: Bioconversion and Biorefinery of C1 Compounds

Eun Yeol Lee, Fu Li Li, Yu Wang, Pramod P. Wangikar, Michael Thomas Guarnieri, Guodong Luan

Research output: Contribution to journalArticlepeer-review

3 Scopus Citations


The past decade has seen significant progress in the field of metabolic engineering and synthetic biology. The exponentially growing multi-omics data and technological advances in the development of efficient genetic manipulation tools and techniques have allowed scientists to explore and expand their understanding of microbial metabolisms and further develop sophisticated engineering strategies to realize the use of industrial "workhorses" and non-conventional microorganisms for sustainable bioconversion and biorefinery. There is of great interest for the research community in using C1 compounds (i.e., CO2, CO/syngas, methane, methanol) as the next generation feedstocks for microbial cell factories and biocatalysts to promote the sustainable development of a green economy (Figure 1). Considering lowering input costs is also a main consideration for successful business ventures, the use of inexpensive, abundant, and widely accessible C1 compounds is envisioned as a promising route for the sustainable production of fine chemicals, fuels, and other high-value products. Many C1 compounds are waste gases from industrial activities and may have detrimental effects on climate change upon emission into the atmosphere. Therefore, promoting the use of C1 compounds as renewable carbon feedstocks can greatly contribute to the reduction of anthropogenic emission of air pollutants.
Original languageAmerican English
Article number778962
Number of pages3
JournalFrontiers in Microbiology
StatePublished - 2021

NREL Publication Number

  • NREL/JA-2700-81616


  • biocatalysts
  • bioconversion
  • biorefinery
  • C1 compounds
  • green economy


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