Editorial: Synthetic Metabolism for the Third-Generation (3G) Biorefineries

Qing Wang, Hai He, Wei Xiong, Peijian Cao, Jian Cheng, Lei Zhao

Research output: Contribution to journalArticlepeer-review


The demand for energy has increased significantly to meet the development of the economy and the increasing population. With the continuous consumption of energy, the shortage of non-renewable resources and the greenhouse effect have aroused worldwide attention. Therefore, the conversion of one-carbon substrates such as formate, methanol, and carbon dioxide (CO2) as sustainable feedstocks into high-value-added products is a potential way to address such concerns. Although one-carbon substrates can be converted into organics by natural pathways, these pathways may not be optimal due to the multiple enzymes involved and remarkable amounts of energy consumption. Thus, synthetic biology, as an emerging field, offers a new approach to boost one-carbon bioconversion.
Original languageAmerican English
Article number1214729
Number of pages2
JournalFrontiers in Bioengineering and Biotechnology
StatePublished - 2023

NREL Publication Number

  • NREL/JA-2700-86652


  • carbon fixation
  • carbon metabolism
  • cell factory design
  • natural products
  • one-carbon feedstock


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