Engineered Microorganisms for the Production of Intermediates and Final Products

Christopher Johnson (Inventor), Peter St. John (Inventor), Gregg Beckham (Inventor), Joshua Elmore (Inventor), Adam Guss (Inventor), Davinia Salvachua Rodriguez (Inventor), Gayle Bentley (Inventor), George Peabody V (Inventor), Taraka Dale (Inventor), Ramesh Jha (Inventor), Niju Narayanan (Inventor)

Research output: Patent


The present disclosure relates to a non-naturally occurring microorganism that includes an endogenous genetic deletion that eliminates the expression of at least a pyruvate kinase, where the genetically modified prokaryotic microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate.
Original languageAmerican English
Patent number11,518,975 B2
Filing date6/12/22
StatePublished - 2022

NREL Publication Number

  • NREL/PT-2800-84758


  • endogenous genetic deletion
  • glucose dehydrogenase
  • phosphoenolpyruvate carboxylase
  • pyruvate kinase


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