Abstract
Polypeptide scaffolds comprising enzymatic proteins are provided. The enzymatic polypeptide scaffolds comprise heterologous enzymes to form a heterologous metabolic pathway, and can be targeted to a substrate through a surface anchoring domain. The enzymatic polypeptide scaffolds leverage the high specificity and affinity protein/protein interaction between the cohesins and dockerins of microorganismal cellulosomes to form custom enzymatic arrays
Original language | American English |
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Patent number | 10,577,633 B2 |
Filing date | 3/03/20 |
State | Published - 2020 |
NREL Publication Number
- NREL/PT-2700-76406
Keywords
- dockerins
- enzymatic proteins
- heterologous enzymes
- microorganismal cellulosomes
- ohesins
- polypeptide scaffolds