Estimation of the Maximum Theoretical Productivity of Fed-Batch Bioreactors

Research output: Contribution to conferencePaperpeer-review


A key step towards the development of an integrated biorefinery is the screening of economically viable processes, which depends sharply on the yields and productivities that can be achieved by an engineered microorganism. In this study, we extend an earlier method which used dynamic optimization to find the maximum theoretical productivity of batch cultures to explicitly include fed-batch bioreactors. In addition to optimizing the intracellular distribution of metabolites between cell growth and product formation, we calculate the optimal control trajectory of feed rate versus time. We further analyze how sensitive the productivity is to substrate uptake and growth parameters.

Original languageAmerican English
Number of pages6
StatePublished - Jul 2017
Event20th IFAC World Congress - Toulouse, France
Duration: 9 Jul 201714 Jul 2017


Conference20th IFAC World Congress
CityToulouse, France

Bibliographical note

Publisher Copyright:
© 2017

NREL Publication Number

  • NREL/CP-2700-70447


  • Fermentation processes
  • nonlinear programming
  • Open-loop control systems
  • Optimal control


Dive into the research topics of 'Estimation of the Maximum Theoretical Productivity of Fed-Batch Bioreactors'. Together they form a unique fingerprint.

Cite this