Abstract
A key step towards the development of an integrated biorefinery is the screening of economically viable processes, which depends sharply on the yields and productivities that can be achieved by an engineered microorganism. In this study, we extend an earlier method which used dynamic optimization to find the maximum theoretical productivity of batch cultures to explicitly include fed-batch bioreactors. In addition to optimizing the intracellular distribution of metabolites between cell growth and product formation, we calculate the optimal control trajectory of feed rate versus time. We further analyze how sensitive the productivity is to substrate uptake and growth parameters.
Original language | American English |
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Pages | 9883-9888 |
Number of pages | 6 |
DOIs | |
State | Published - Jul 2017 |
Event | 20th IFAC World Congress - Toulouse, France Duration: 9 Jul 2017 → 14 Jul 2017 |
Conference
Conference | 20th IFAC World Congress |
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City | Toulouse, France |
Period | 9/07/17 → 14/07/17 |
Bibliographical note
Publisher Copyright:© 2017
NREL Publication Number
- NREL/CP-2700-70447
Keywords
- Fermentation processes
- nonlinear programming
- Open-loop control systems
- Optimal control