Leveraging Algal Omics to Reveal Potential Targets for Augmenting TAG Accumulation

Neha Arora; Philip T. Pienkos; Vikas Pruthi; Krishna Mohan Poluri; Michael T. Guarnieri

doi:10.1016/j.biotechadv.2018.04.005

Leveraging Algal Omics to Reveal Potential Targets for Augmenting TAG Accumulation

Neha Arora, Philip T. Pienkos, Vikas Pruthi, Krishna Mohan Poluri, Michael T. Guarnieri

Indian Institute of Technology Roorkee

Research output: Contribution to journal › Review article › peer-review

80 Scopus Citations

Abstract

Ongoing global efforts to commercialize microalgal biofuels have expedited the use of multi-omics techniques to gain insights into lipid biosynthetic pathways. Functional genomics analyses have recently been employed to complement existing sequence-level omics studies, shedding light on the dynamics of lipid synthesis and its interplay with other cellular metabolic pathways, thus revealing possible targets for metabolic engineering. Here, we review the current status of algal omics studies to reveal potential targets to augment TAG accumulation in various microalgae. This review specifically aims to examine and catalog systems level data related to stress-induced TAG accumulation in oleaginous microalgae and inform future metabolic engineering strategies to develop strains with enhanced bioproductivity, which could pave a path for sustainable green energy.

Original language	American English
Pages (from-to)	1274-1292
Number of pages	19
Journal	Biotechnology Advances
Volume	36
Issue number	4
DOIs	https://doi.org/10.1016/j.biotechadv.2018.04.005 https://doi.org/10.1016/j.biotechadv.2018.04.005
State	Published - 2018

Bibliographical note

Publisher Copyright:
© 2018 The Authors

NREL Publication Number

NREL/JA-5100-71479

Keywords

Algal
Metabolomic
Omics
Proteomics
Transcriptomics
Triacylglycerol

Access to Document

https://www.nrel.gov/docs/fy18osti/71479.pdf

Cite this

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title = "Leveraging Algal Omics to Reveal Potential Targets for Augmenting TAG Accumulation",

abstract = "Ongoing global efforts to commercialize microalgal biofuels have expedited the use of multi-omics techniques to gain insights into lipid biosynthetic pathways. Functional genomics analyses have recently been employed to complement existing sequence-level omics studies, shedding light on the dynamics of lipid synthesis and its interplay with other cellular metabolic pathways, thus revealing possible targets for metabolic engineering. Here, we review the current status of algal omics studies to reveal potential targets to augment TAG accumulation in various microalgae. This review specifically aims to examine and catalog systems level data related to stress-induced TAG accumulation in oleaginous microalgae and inform future metabolic engineering strategies to develop strains with enhanced bioproductivity, which could pave a path for sustainable green energy.",

keywords = "Algal, Metabolomic, Omics, Proteomics, Transcriptomics, Triacylglycerol",

author = "Neha Arora and Pienkos, {Philip T.} and Vikas Pruthi and Poluri, {Krishna Mohan} and Guarnieri, {Michael T.}",

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year = "2018",

doi = "10.1016/j.biotechadv.2018.04.005",

language = "American English",

volume = "36",

pages = "1274--1292",

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T1 - Leveraging Algal Omics to Reveal Potential Targets for Augmenting TAG Accumulation

AU - Arora, Neha

AU - Pienkos, Philip T.

AU - Pruthi, Vikas

AU - Poluri, Krishna Mohan

AU - Guarnieri, Michael T.

PY - 2018

Y1 - 2018

N2 - Ongoing global efforts to commercialize microalgal biofuels have expedited the use of multi-omics techniques to gain insights into lipid biosynthetic pathways. Functional genomics analyses have recently been employed to complement existing sequence-level omics studies, shedding light on the dynamics of lipid synthesis and its interplay with other cellular metabolic pathways, thus revealing possible targets for metabolic engineering. Here, we review the current status of algal omics studies to reveal potential targets to augment TAG accumulation in various microalgae. This review specifically aims to examine and catalog systems level data related to stress-induced TAG accumulation in oleaginous microalgae and inform future metabolic engineering strategies to develop strains with enhanced bioproductivity, which could pave a path for sustainable green energy.

AB - Ongoing global efforts to commercialize microalgal biofuels have expedited the use of multi-omics techniques to gain insights into lipid biosynthetic pathways. Functional genomics analyses have recently been employed to complement existing sequence-level omics studies, shedding light on the dynamics of lipid synthesis and its interplay with other cellular metabolic pathways, thus revealing possible targets for metabolic engineering. Here, we review the current status of algal omics studies to reveal potential targets to augment TAG accumulation in various microalgae. This review specifically aims to examine and catalog systems level data related to stress-induced TAG accumulation in oleaginous microalgae and inform future metabolic engineering strategies to develop strains with enhanced bioproductivity, which could pave a path for sustainable green energy.

KW - Algal

KW - Metabolomic

KW - Omics

KW - Proteomics

KW - Transcriptomics

KW - Triacylglycerol

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U2 - 10.1016/j.biotechadv.2018.04.005

DO - 10.1016/j.biotechadv.2018.04.005

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SN - 0734-9750

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JO - Biotechnology Advances

JF - Biotechnology Advances

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ER -

Leveraging Algal Omics to Reveal Potential Targets for Augmenting TAG Accumulation

Abstract

Bibliographical note

NREL Publication Number

Keywords

Access to Document

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