Leveraging Algal Omics to Reveal Potential Targets for Augmenting TAG Accumulation

Neha Arora, Philip T. Pienkos, Vikas Pruthi, Krishna Mohan Poluri, Michael T. Guarnieri

Research output: Contribution to journalReview articlepeer-review

70 Scopus Citations


Ongoing global efforts to commercialize microalgal biofuels have expedited the use of multi-omics techniques to gain insights into lipid biosynthetic pathways. Functional genomics analyses have recently been employed to complement existing sequence-level omics studies, shedding light on the dynamics of lipid synthesis and its interplay with other cellular metabolic pathways, thus revealing possible targets for metabolic engineering. Here, we review the current status of algal omics studies to reveal potential targets to augment TAG accumulation in various microalgae. This review specifically aims to examine and catalog systems level data related to stress-induced TAG accumulation in oleaginous microalgae and inform future metabolic engineering strategies to develop strains with enhanced bioproductivity, which could pave a path for sustainable green energy.

Original languageAmerican English
Pages (from-to)1274-1292
Number of pages19
JournalBiotechnology Advances
Issue number4
StatePublished - 2018

Bibliographical note

Publisher Copyright:
© 2018 The Authors

NREL Publication Number

  • NREL/JA-5100-71479


  • Algal
  • Metabolomic
  • Omics
  • Proteomics
  • Transcriptomics
  • Triacylglycerol


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