Predicting Drug Resistance Using Deep Mutational Scanning: Article No. 2265

Gur Pines, Reilly Fankhauser, Carrie Eckert

Research output: Contribution to journalArticlepeer-review

5 Scopus Citations

Abstract

Drug resistance is a major healthcare challenge, resulting in a continuous need to develop new inhibitors. The development of these inhibitors requires an understanding of the mechanisms of resistance for a critical mass of occurrences. Recent genome editing technologies based on high-throughput DNA synthesis and sequencing may help to predict mutations resulting in resistance by testing large mutagenesis libraries. Here we describe the rationale of this approach, with examples and relevance to drug development and resistance in malaria.
Original languageAmerican English
Number of pages13
JournalMolecules
Volume25
Issue number9
DOIs
StatePublished - 2020

NREL Publication Number

  • NREL/JA-2700-76627

Keywords

  • drug resistance
  • DXR
  • fosmidomycin
  • genome editing
  • sequence to activity mapping

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