Reply to Cosgrove: Non-Enzymatic Action of Expansins

Research output: Contribution to journalArticlepeer-review


In our computational study, we use molecular simulations to substantiate a hypothetical mechanism for glycosidic bond cleavage in the presence of a single catalytic acid at the active site of the mutant D10N HiCel45A. In addition to discussing this plausible mechanism from the context of structurally related MltA lytic transglycosylase and subfamily C GH45s, we also suggest the implications of the plausible mechanism for our current understanding of the action of expansins and lytic transglycosylases.
Original languageAmerican English
Pages (from-to)6783
Number of pages1
JournalJournal of Biological Chemistry
Issue number19
StatePublished - 2020

NREL Publication Number

  • NREL/JA-2800-77199


  • expansins
  • molecular mechanisms


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