Abstract
In our computational study, we use molecular simulations to substantiate a hypothetical mechanism for glycosidic bond cleavage in the presence of a single catalytic acid at the active site of the mutant D10N HiCel45A. In addition to discussing this plausible mechanism from the context of structurally related MltA lytic transglycosylase and subfamily C GH45s, we also suggest the implications of the plausible mechanism for our current understanding of the action of expansins and lytic transglycosylases.
| Original language | American English |
|---|---|
| Pages (from-to) | 6783 |
| Number of pages | 1 |
| Journal | Journal of Biological Chemistry |
| Volume | 295 |
| Issue number | 19 |
| DOIs | |
| State | Published - 2020 |
NLR Publication Number
- NREL/JA-2800-77199
Keywords
- expansins
- molecular mechanisms
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