Succinic Acid Production from Lignocellulosic Hydrolysate by Basfia succiniciproducens

Davinia Salvachúa, Holly Smith, Peter C. St. John, Ali Mohagheghi, Darren J. Peterson, Brenna A. Black, Nancy Dowe, Gregg T. Beckham

Research output: Contribution to journalArticlepeer-review

61 Scopus Citations


The production of chemicals alongside fuels will be essential to enhance the feasibility of lignocellulosic biorefineries. Succinic acid (SA), a naturally occurring C4-diacid, is a primary intermediate of the tricarboxylic acid cycle and a promising building block chemical that has received significant industrial attention. Basfia succiniciproducens is a relatively unexplored SA-producing bacterium with advantageous features such as broad substrate utilization, genetic tractability, and facultative anaerobic metabolism. Here B. succiniciproducens is evaluated in high xylose-content hydrolysates from corn stover and different synthetic media in batch fermentation. SA titers in hydrolysate at an initial sugar concentration of 60 g/L reached up to 30 g/L, with metabolic yields of 0.69 g/g, and an overall productivity of 0.43 g/L/h. These results demonstrate that B. succiniciproducens may be an attractive platform organism for bio-SA production from biomass hydrolysates.

Original languageAmerican English
Pages (from-to)558-566
Number of pages9
JournalBioresource Technology
StatePublished - 1 Aug 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd.

NREL Publication Number

  • NREL/JA-5100-66481


  • Actinobacillus succinogenes
  • Biochemical
  • Biorefinery
  • Corn stover
  • Xylose


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