Systems Biology-Guided Understanding of White-Rot Fungi for Biotechnological Applications: A Review

Teeratas Kijpornyongpan, Alexa Schwartz, Allison Yaguchi, Davinia Salvachua

Research output: Contribution to journalArticlepeer-review

33 Scopus Citations


Plant-derived biomass is the most abundant biogenic carbon source on Earth. Despite this, only a small clade of organisms known as white-rot fungi (WRF) can efficiently break down both the polysaccharide and lignin components of plant cell walls. This unique ability imparts a key role for WRF in global carbon cycling and highlights their potential utilization in diverse biotechnological applications. To date, research on WRF has primarily focused on their extracellular ‘digestive enzymes’ whereas knowledge of their intracellular metabolism remains underexplored. Systems biology is a powerful approach to elucidate biological processes in numerous organisms, including WRF. Thus, here we review systems biology methods applied to WRF to date, highlight observations related to their intracellular metabolism, and conduct comparative extracellular proteomic analyses to establish further correlations between WRF species, enzymes, and cultivation conditions. Lastly, we discuss biotechnological opportunities of WRF as well as challenges and future research directions.

Original languageAmerican English
Article numberArticle No. 104640
Number of pages24
Issue number7
StatePublished - 15 Jul 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s)

NREL Publication Number

  • NREL/JA-2800-81998


  • fungal biotechnology
  • omics
  • systems biology
  • white-rot fungi


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