Target Highlights in CASP14: Analysis of Models by Structure Providers

Leila Alexander, Rosalba Lepore, Andriy Kryshtafovych, Athanassios Adamopoulos, Markus Alahuhta, Ann Arvin, Yannick Bomble, Bettina Bottcher, Cecile Breyton, Valerio Chiarini, Naga babu Chinnam, Wah Chiu, Krzysztof Fidelis, Rhys Grinter, Gagan Gupta, Marcus Hartmann, Christopher Hayes, Tatjana Heidebrecht, Andrea Ilari, Andrzej JoachimiakYoungchang Kim, Romain Linares, Andrew Lovering, Vladimir Lunin, Andrei Lupas, Cihan Makbul, Karolina Michalska, John Moult, Prasun Mukherjee, William Nutt, Stefan Oliver, Anastassis Perrakis, Lucy Stols, John Tainer, Maya Topf, Susan Tsutakawa, Mauricio Valdivia-Delgado, Torsten Schwede

Research output: Contribution to journalArticlepeer-review

22 Scopus Citations


The biological and functional significance of selected Critical Assessment of Techniques for Protein Structure Prediction 14 (CASP14) targets are described by the authors of the structures. The authors highlight the most relevant features of the target proteins and discuss how well these features were reproduced in the respective submitted predictions. The overall ability to predict three-dimensional structures of proteins has improved remarkably in CASP14, and many difficult targets were modeled with impressive accuracy. For the first time in the history of CASP, the experimentalists not only highlighted that computational models can accurately reproduce the most critical structural features observed in their targets, but also envisaged that models could serve as a guidance for further studies of biologically-relevant properties of proteins.

Original languageAmerican English
Pages (from-to)1647-1672
Number of pages26
JournalProteins: Structure, Function and Bioinformatics
Issue number12
StatePublished - 2021

Bibliographical note

Publisher Copyright:
© 2021 The Authors. Proteins: Structure, Function, and Bioinformatics published by Wiley Periodicals LLC.

NREL Publication Number

  • NREL/JA-2700-79966


  • CASP
  • community-wide experiment
  • cryo-EM
  • protein structure prediction
  • X-ray crystallography


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