TY - JOUR
T1 - Target Highlights in CASP14: Analysis of Models by Structure Providers
AU - Alexander, Leila
AU - Lepore, Rosalba
AU - Kryshtafovych, Andriy
AU - Adamopoulos, Athanassios
AU - Alahuhta, Markus
AU - Arvin, Ann
AU - Bomble, Yannick
AU - Bottcher, Bettina
AU - Breyton, Cecile
AU - Chiarini, Valerio
AU - Chinnam, Naga babu
AU - Chiu, Wah
AU - Fidelis, Krzysztof
AU - Grinter, Rhys
AU - Gupta, Gagan
AU - Hartmann, Marcus
AU - Hayes, Christopher
AU - Heidebrecht, Tatjana
AU - Ilari, Andrea
AU - Joachimiak, Andrzej
AU - Kim, Youngchang
AU - Linares, Romain
AU - Lovering, Andrew
AU - Lunin, Vladimir
AU - Lupas, Andrei
AU - Makbul, Cihan
AU - Michalska, Karolina
AU - Moult, John
AU - Mukherjee, Prasun
AU - Nutt, William
AU - Oliver, Stefan
AU - Perrakis, Anastassis
AU - Stols, Lucy
AU - Tainer, John
AU - Topf, Maya
AU - Tsutakawa, Susan
AU - Valdivia-Delgado, Mauricio
AU - Schwede, Torsten
N1 - Publisher Copyright:
© 2021 The Authors. Proteins: Structure, Function, and Bioinformatics published by Wiley Periodicals LLC.
PY - 2021
Y1 - 2021
N2 - The biological and functional significance of selected Critical Assessment of Techniques for Protein Structure Prediction 14 (CASP14) targets are described by the authors of the structures. The authors highlight the most relevant features of the target proteins and discuss how well these features were reproduced in the respective submitted predictions. The overall ability to predict three-dimensional structures of proteins has improved remarkably in CASP14, and many difficult targets were modeled with impressive accuracy. For the first time in the history of CASP, the experimentalists not only highlighted that computational models can accurately reproduce the most critical structural features observed in their targets, but also envisaged that models could serve as a guidance for further studies of biologically-relevant properties of proteins.
AB - The biological and functional significance of selected Critical Assessment of Techniques for Protein Structure Prediction 14 (CASP14) targets are described by the authors of the structures. The authors highlight the most relevant features of the target proteins and discuss how well these features were reproduced in the respective submitted predictions. The overall ability to predict three-dimensional structures of proteins has improved remarkably in CASP14, and many difficult targets were modeled with impressive accuracy. For the first time in the history of CASP, the experimentalists not only highlighted that computational models can accurately reproduce the most critical structural features observed in their targets, but also envisaged that models could serve as a guidance for further studies of biologically-relevant properties of proteins.
KW - CASP
KW - community-wide experiment
KW - cryo-EM
KW - protein structure prediction
KW - X-ray crystallography
UR - http://www.scopus.com/inward/record.url?scp=85116478711&partnerID=8YFLogxK
U2 - 10.1002/prot.26247
DO - 10.1002/prot.26247
M3 - Article
C2 - 34561912
AN - SCOPUS:85116478711
SN - 0887-3585
VL - 89
SP - 1647
EP - 1672
JO - Proteins: Structure, Function and Bioinformatics
JF - Proteins: Structure, Function and Bioinformatics
IS - 12
ER -